Italian captain Michele Lamaro was dropped on the bench against Ireland.
Lamaro started his final 24 Six Nations matches, but was replaced by Manuel Zuriani, who came out of the bench in the last four games and started equipment from six countries last year against Ireland.
“The match has developed for over 80 minutes and the contributions of all players on the match list will be fundamental,” Quesada said.
“Zuliani deserves the opportunity from the first minute, and at the same time, he wants to show greater leadership on the pitch at the final stage of the game.”
Centre Juan Ignacio Brex took over as captain for the second time, facing New Zealand, where Ramaro was injured in November last year.
Ange Capuozzo returns to the wings and Tommaso Allan returns to the side with Matt Gallagher in a 47-24 loss to England last Sunday after a knee injury in his six-country debut.
Scrum half Martin Pagelero returns to replace Stephen Barney and reclaims the eighth shirt from Ross Vintent, where Lorenzo Canone scored a try against England.
There are two changes in the front row, with Jammar Corkkesi and Simone Ferrari coming to Giacomo Nicoterra and Marcolicioni, and Lockedinorum replacing Nicolo Cannon.
Italy hopes to avoid the bottom and wooden spoon for the second year in a row, but despite the only victory in this championship against Wales, Quesada’s side is still one point ahead of Wales, who plays England.
The Italian, who suffered a fierce back-to-back defeat against France and the UK, aims to finish the campaign in style in front of the sold-out Studio Olimpico.
Traveling Irish would have hoped to be able to celebrate the Grand Slam in the Italian capital on St. Patrick’s weekend, but last Saturday pushed France with a 42-27 loss in Dublin.
Ireland aims for a bonus point victory to give them a chance to win three consecutive titles, but they still need France and Britain to not win the game.
Italian XV against Ireland:
Danilo Fischelti, Jammarco Russchesi, Simone Ferrari, Dino Rum, Federico Luzza, Sebastian Negri, Manuel Zuliani, Lorenzo Canon, Martin Page Riaro, Paolo Garbisi, Monty Ioan, Tonmaso Menoncero, Gian Ignacio Brex (captain)
Alternatives: Giacomo Nicotera, Mirco Spagnolo, Giosue Zilocchi, Niccolo Cannone, Michele Lamaro, Ross Vintcent, Stephen Varney, and Leonardo Marin.
1:00
Italy secures a historic victory over Ireland
Ahead of the final round fixture this weekend, we will relive three classic Six Nations games between Ireland and Italy.
– Overreaction: Does Marcus Smith cement the full back spot? Should Ireland reset?
– Tom Hamilton of Twickenham: The UK will work in Italy and maintain title hopes
– Can you replace Warren Gatland as Wales head coach?
– Watch: Relax some of the Six Nations classic games
– Six Nations and Women’s Six Nations: Full Fixture List